Please visit http://www.arksciences.com/faq.html and you will be surprised. I am part of the Executive Team at Ark Sciences and we routinely toast with Esterilsol at our meetings. Esterilsol is a mixture of Zinc Gluconate and Arginine in water with no preservatives and a pH of 7. They are both supplements you will find in a health food store. Traditionally, chemical neutering was cruel with toxic chemicals being injected into the testicles. Esterilsol is just the opposite. More than 98% of dogs never need any medical intervention after the 2-minute procedure than can be done without sedation in most cases.